Index to This Blog

Comprehensive Index of Posts to Josh Mitteldorf’s Aging Blog  (2012 – 

Sept-Dec 2012
Can telomere herapies help us live longer?
Vitamin D and Aspirin
Is Metformin an Anti-Aging Drug?
Anti-oxidants: A Disappointment or Worse
Mortality and Life Expectancy
Telomerase as a Fountain of Youth
What would it mean to live forever?
Rising Life Expectancy, but not in the US
Can having children help you live longer?
Ideal Weight an Illusion

Jan-Mar 2013
Is Aging Active Self-Destruction?
How can we Stop Killing Ourselves (4 modes of programmed self-destruction)
SkQ: Putting the Brakes on Cell Suicide
Spectacular success with Buckyballs
Declining Force of Natural Selection
The China Study (veganism)
DNA Methylation – an aging clock
Cold temperature, life span, rate-of-living hypothesis
Thymic Involution
Resveratrol & Sirtuins
Deprenyl
Young Blood, Katcher, Heterochronic Plasma Exchange

Apr-Jun 2013
Immune System and Cancer
Mutilevel Selection and Evolution of Aging I
Mutilevel Selection and Evolution of Aging II
Intermittent Fasting
Nervous System controls rate of aging
Methionine Restriction
“Natural anti-aging” an oxymoron
Short takes from AGE mtg 2013
How to be skinny (weight loss tips)
Dietary Salt: Science corrects a long-standing error
Rhodiola

July-Sept 2013
Demographic Theory of Aging
Cell Phones and Cancer
Evolution of Evolution (Evolvability 1)
Evolution of Evolution (Evolvability 2)
Osteoporosis
How does aspirin work?
(Does it extend life by thinning the blood or by reducing inflammation?  Only the latter can be considered truly anti-aging)
Meditation and Longevity
Natural selection has rewarded those who contribute to the community with long life
New Take on Free Radicals
Conference Report:  SENS-6
Creative deprivation: how to get less from your food
Aging and LIfe Extension: Unexpected Lessons from Evolution

Oct-Dec 2013
Combining biochemical pathways: recipe for the Youth Pill
How is sex like Obamacare? (The conundrum of the evolution of sex)
Within the paradigm of the “Selfish Gene”, there is no way that gene sharing could have evolved as an adaptation.  But sex DID evolve.  This alone should make us wary of the selfish gene.)
How does the body’s hormonal signaling change with age?
Signal molecules in the blood: what do we have too much as we age?
Signal molecules in the blood: what do we lose with age?
Exercise because it feels good!  (Longer life is a fringe benefit)
The Selfish Gene vs Multilevel Selection: Aging doesn’t Fit
The Selfish Gene can’t Explain Aging – but neither can Multi-level selection
Political and “moral” opposition to the anti-aging program
Anti-aging anti-depressants
Love of life? or Fear of death?  Why do we wish to live longer?

Jan-Mar 2014
Comprehensive Review of Anti-aging Supplements  (points to AgingAdvice.org)
MitoQ and SkQ – designer anti-oxidants that are targeted to the mitochondria
Telomerase activation: The most promising medical technology on the horizon
A new way to eliminate senescent cells and a simpler way to make stem cells
A heavy hitter weighs in against evolutionary theory
Anti-oxidants can nullify the benefits of exercise
A well-known Anti-aging Supplement
One-minute Workouts
Mitigating risk of Alzheimer’s Disease: More important than we thought
A one-man experiment in radical anti-aging
“Life extension supplements” – a reality check

Apr-Jun 2014
Salt is good for you
Build exercise into your day
The body doesn’t just wear out as we get older (entropy, damage theories of aging)
Lamarckian Inheritance: Passing what you have learned to your children
Whole Turmeric better than Curcumin?
GDF11 – A Hormonal Candidate for Rejuvenation (parabiosis, Wager, Conboy, Rubin)
Cholesterol Controversy – Part I
Cholesterol, Part II
Three-day fast: Day four (Valter Longo)
Human mortality, Individual and Collective (environmental politics, ecosystem collapse, existential threats)
Anisimov – Russian Optimist on Longevity (short peptides, epithalamin, epitalon)

July-Sept 2014
Vegetarian diet contributes to longevity
Origin of Life, Part I
Origin of Life, Part II
How Aging contributes to Evolvability
Oxytocin, the “love hormone”, is also a longevity hormone
Questioning the FDA decision to back away from recommending aspirin
Notes from Rejuvenation Biotech Conference in Santa Clara
Imminent test of transfusions with young blood as a treatment for Alzheimer’s
Sleep and Longevity
CRISPR for gene therapy and maybe epigenetic reprogramming
Substituting an inefficient means of DNA repair is one way the body slowly kills itself with age
Aging in protozoa is a means of enforcing the imperative for sexual sharing of genes

October-December 2014
Anti-Aging Oxymorons and Anti-oxymorons  Why “natural anti-aging” can never work
Lithium for Life Extension?
Response to Gretchen Reynolds, Poking Fun at Longevity Science
Open Letter to Google CaLiCo on Priorities in Research
Conference notes: Center for Aging Research, Sherbrooke, QC
Nicotinamide Riboside–Where’s the Beef?
Three Technologies to Watch (1)Thymus regrowth w/ FOXN1;  (2) New anti-inflammatory drugs based on ARF6 inhibitors;  (3) Telomere length directly affects gene expression
Regeneration in mammals — Ancient capacity is not lost but actively suppressed
What doesn’t kill me makes me stronger
Caloric Restriction, Hormesis and what they teach us about Evolution
Ginseng for Longevity?
Where do we Live? In our quest for a longer life, I often assume “I am my brain”.  There are reasons from neuroscience and quantum physics to question this perspective.

Jan-Mar 2015
What is aging? Most scientists still get it wrong (The body doesn’t just wear out. Death is programmed into our genes.)
Programmed death, H. pylori and the legacy of George Williams (evolution and gut bacteria)
MYC: bad and good, but more bad than good
Do we really need epidemiology to tell us to get off our duffs? (Common sense experience about exercise and sedentary time)
Anti-Aging Pills in the News (Novartis and Elysium Health)
Ideology is Holding Back Aging Research
“What Looks like Cooperation is Really Selfishness” (Critique of the Selfish Gene)
Kill Senescent Cells Before They Kill You
Tomorrow’s Anti-Aging Therapies, Available Today (Bioviva)
Fertility is Kaput, but Life Goes On (Post-Reproductive Life Span)

Apr-Jun 2015

Magnesium
Telomerase Does Not Cause Cancer
New Study Correlates Telomere Length with Human Mortality
Pterostilbene
Caution follows last year’s excitement about GDF11
Review of The Vital Question by Nick Lane, Part 1,  Part 2,  Part 3
Preserving Insulin Sensitivity–the Anti-Diabetes Diet
Is there an aging clock in the hypothalamus? (Orexin, Neuropeptide Y)
Toward a Pill to Enable Regeneration 
Correlation and causation;  Nuts and Chocolate

Longo on how you can eat while fasting;  Barzilai’s campaign to have aging recognized as a disease

Jul-Sep 2015

Funding Policies Distort Science
Aging in Microbes
(despite theory that forbids it, there is aging in protozoans and even bacteria)
Update and disclaimer — the Longo Fasting-mimicking Diet, including Recipes
Parkinson’s Disease — Can anything be done?
Overstated claims and oversimple theories, including the
“Simple genetic switch” in C elegans,  Autophagy, Glycine & mitochondria,
GDF11 and TGF-β)
Orcas and Elephants–Aging and the Taboo Subject of Population Regulation
     Review of Carl Safina’s book, Beyond Words.
Report from Rejuvenation Biotech 2015

(Thymus regeneration, Bruce Ames & Rhonda Patrick, plasma transfusion update
Wuyi Kong and NPRCPs)
HGH and IGF–Promise and Danger
Untested Treatments for Longevity, and How to Test Them
      (Redundancy and synergy in combining anti-aging treatments)
Promise of Novel Alzheimer’s Treatments
Growth and Aging; Myostatin and Health

Oct-Dec 2015
Can botanicals replace metformin? Jiaogulan, Berberine and Gymnema 
From Roscoff, with Rotifers
 – What I learned at the Monod Conference on comparative biology of aging
Does donating blood extend your life expectancy?

Anti-Aging Medicine: Two Paths Diverge
 – Can aging be reversed with biochemical signals?
We Know Nothing about Longevity Drug Interactions – a proposal for efficiently finding the best dynergies among many potential treatments 
Global Consequences of Increased Human Longevity – Life extensionists have an vital interest and responsibility to preserve the planet.

Jan-Jun 2016
Is Aging Controlled from the Brain? NPY and ALK5
‘One of the most important aging discoveries ever’ “Senolytics” are agents that kill cells that have become senescent (and toxic).
When your doctor suggests statins (Part 1: Mechanism of Action)

Cholesterol and inflammation; Statins and alternatives (Part II)
Politics drives a promising nutraceutical underground  Anatabine
Retrotransposons: The Lamarckian Link
  A mechanism by which the body re-engineers its own genome.
Aging is a Military Coup
 Systems that evolved to defend the body against invaders turn self-destructive and destroy the body late in life.
Epigenetics of Aging and Prospects for Rejuvenation
“No Animal Dies of Old Age in the Wild” The declining force of natural selection is the foundation of all evolutionary theories of aging.  But it doesn’t decline enough to explain anything.
Cell Phones can Cause Cancer – It’s worthwhile to take precautions with microwaves.
A germ theroy of aging?
 A new paper proposes that plaques in Alzheimer’s Disease come from inflammatory response to brain infections.
Lamarck Update
 – Evolutionary scientists have assumed for a century that traits acquired in a lifetime can’t be passed to offspring.  Now it’s clear they were wrong.  How wrong?
Rapamycin Redux – Rapamycin is the most effective life extension drug yet tested in rodents.  Is it safe for humans? 
CRISPR update – We’re making progress gaining control over gene expression faster than we are learning what to do with our new power.

Jul-Dec 2016

Video: “Natural Anti-aging” is an oxymoron
Social Correlates of Longevity 1: Social status and depression, activism vs powerlessness
Social Correlates of Longevity 2: Family
Arthritis: Its importance, its ubiquity, and suggested treatment approaches
Nutritional Geometry 1: Most of us eat too much protein
Nutritional Geometry 2: Carb Restriction
Nutritional Geometry 3: Ketosis— benefits & risks of oil-rich diets
Post-Reproductive Life Span in C. elegans—How did worms evolve a life span that continues long beyond the end of their fertility?
Putting the “system” back in Systems Biology (Report from Cold Spring Harbor Asia Conference, October, 2016)
In an age of epigenetics, does antagonistic pleiotropy still make sense?
Traditional Chinese Medicines for Longevity
Do we have to worry about telomeres being “too long”?
Yamanaka Factors (which turn normal cells into stem cells) used to rejuvenate mice
Epigenetics and the Direction of Anti-Aging Science

9 thoughts on “Index to This Blog

  1. D-Limonene: Wondering if anyone has information on this citrus oil derived from the rinds of grapefruit, orange or lemon. It recently gained attention as an effective treatment for GERD but was known in skin cancer circles for being an interesting compound that when added to diet, decreased incidents of melanoma to a statistically significant degree. There have been many studies that confirm this, notably, underfunded but promising work done by Dr. Sherry Chow at University of Arizona. It appears D-Limonene may have strong action on other types of cancer, particularly breast and prostate. Interesting that it is ubiquitous, inexpensive and has very few side effects, and coincidentally has received little funding for research despite very promising, credible studies that go back 20 years. Here’s a link:
    http://www.ncbi.nlm.nih.gov/pubmed/1464157

    • It should not be surprising that limonene might help prevent skin cancer. Limonene is found in the rinds of citrus fruit, which of course are exposed to sunlight. Sunlight causes some bad chemical reactions like causing DNA dimers to form. So it may be that limonene is there in citrus rinds to prevent such reactions in the citrus, and can also prevent such reactions in human skin. Judging from its chemical structure with double bonds, I suspect it is an antioxidant.

  2. Oh shame to Man!
    Devil with devil dammed.
    Firm concord holds, whilst humans disagree
    Of creatures rational and full of hope.
    Yet live in hatred, emnity and strife and levy cruel wars,
    Wasting the earth, each other to destroy,
    As if, which might induce us to accord,
    Man hath not enemies enough besides,
    Who day and night for his destruction wait!

    JOHN MILTON, from Paradise Lost

  3. Josh, recently you discussed using Lithium for gene suppression. But in the discussion you stated that Lithium increased nf-kb expression. It didn’t seem right to me, so I did a bit of digging and found Lithium to be a potent inhibitor of nf-kb. This in turn started me thinking on nf-kb itself and how it appears to only exist to kill you.
    Would you please consider doing an article on it and how to control it, in the not to distant future.

  4. Josh
    I found your blog 2 months ago. It is fantastic. Congratulations. I have one query. Do you have any thing further on Vitamin D3. There is your post back in 2011 and I have read it. But recently I read a book by Jeff Bowles called “Vitamin D3 Miracle”. He suggests that taking large doses of D3 along with Vitamin k2 can cure numerous diseases many of which accompany aging. Any thoughts on this ?

    Thanks
    Bill

    • I know Jeff, and think of him as very smart, basically trustworthy, but his evidence is anecdotal. I don’t think large doses of vitamin D are going to hurt you, but whether you experience a “miracle” is a function of your individual metabolism. I encourage you to experiment.

  5. Josh,
    I greatly appreciate this blog, keep it up. Have you investigated Alpha Ketoglutarate? I haven’t found anything on it here, but would be interested in your insights, including this study found in PubMed: “The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR.”
    Thanks,
    Neil

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