Comprehensive Index of Posts to Josh Mitteldorf’s Aging Blog (2012 –
Can telomere herapies help us live longer?
Vitamin D and Aspirin
Is Metformin an Anti-Aging Drug?
Anti-oxidants: A Disappointment or Worse
Mortality and Life Expectancy
Telomerase as a Fountain of Youth
What would it mean to live forever?
Rising Life Expectancy, but not in the US
Can having children help you live longer?
Ideal Weight an Illusion
Is Aging Active Self-Destruction?
How can we Stop Killing Ourselves (4 modes of programmed self-destruction)
SkQ: Putting the Brakes on Cell Suicide
Spectacular success with Buckyballs
Declining Force of Natural Selection
The China Study (veganism)
DNA Methylation – an aging clock
Cold temperature, life span, rate-of-living hypothesis
Resveratrol & Sirtuins
Young Blood, Katcher, Heterochronic Plasma Exchange
Immune System and Cancer
Mutilevel Selection and Evolution of Aging I
Mutilevel Selection and Evolution of Aging II
Nervous System controls rate of aging
“Natural anti-aging” an oxymoron
Short takes from AGE mtg 2013
How to be skinny (weight loss tips)
Dietary Salt: Science corrects a long-standing error
Demographic Theory of Aging
Cell Phones and Cancer
Evolution of Evolution (Evolvability 1)
Evolution of Evolution (Evolvability 2)
How does aspirin work?
(Does it extend life by thinning the blood or by reducing inflammation? Only the latter can be considered truly anti-aging)
Meditation and Longevity
Natural selection has rewarded those who contribute to the community with long life
New Take on Free Radicals
Conference Report: SENS-6
Creative deprivation: how to get less from your food
Aging and LIfe Extension: Unexpected Lessons from Evolution
Combining biochemical pathways: recipe for the Youth Pill
How is sex like Obamacare? (The conundrum of the evolution of sex)
Within the paradigm of the “Selfish Gene”, there is no way that gene sharing could have evolved as an adaptation. But sex DID evolve. This alone should make us wary of the selfish gene.)
How does the body’s hormonal signaling change with age?
Signal molecules in the blood: what do we have too much as we age?
Signal molecules in the blood: what do we lose with age?
Exercise because it feels good! (Longer life is a fringe benefit)
The Selfish Gene vs Multilevel Selection: Aging doesn’t Fit
The Selfish Gene can’t Explain Aging – but neither can Multi-level selection
Political and “moral” opposition to the anti-aging program
Love of life? or Fear of death? Why do we wish to live longer?
Comprehensive Review of Anti-aging Supplements (points to AgingAdvice.org)
MitoQ and SkQ – designer anti-oxidants that are targeted to the mitochondria
Telomerase activation: The most promising medical technology on the horizon
A new way to eliminate senescent cells and a simpler way to make stem cells
A heavy hitter weighs in against evolutionary theory
Anti-oxidants can nullify the benefits of exercise
A well-known Anti-aging Supplement
Mitigating risk of Alzheimer’s Disease: More important than we thought
A one-man experiment in radical anti-aging
“Life extension supplements” – a reality check
Salt is good for you
Build exercise into your day
The body doesn’t just wear out as we get older (entropy, damage theories of aging)
Lamarckian Inheritance: Passing what you have learned to your children
Whole Turmeric better than Curcumin?
GDF11 – A Hormonal Candidate for Rejuvenation (parabiosis, Wager, Conboy, Rubin)
Cholesterol Controversy – Part I
Cholesterol, Part II
Three-day fast: Day four (Valter Longo)
Human mortality, Individual and Collective (environmental politics, ecosystem collapse, existential threats)
Anisimov – Russian Optimist on Longevity (short peptides, epithalamin, epitalon)
Vegetarian diet contributes to longevity
Origin of Life, Part I
Origin of Life, Part II
How Aging contributes to Evolvability
Oxytocin, the “love hormone”, is also a longevity hormone
Questioning the FDA decision to back away from recommending aspirin
Notes from Rejuvenation Biotech Conference in Santa Clara
Imminent test of transfusions with young blood as a treatment for Alzheimer’s
Sleep and Longevity
CRISPR for gene therapy and maybe epigenetic reprogramming
Substituting an inefficient means of DNA repair is one way the body slowly kills itself with age
Aging in protozoa is a means of enforcing the imperative for sexual sharing of genes
Anti-Aging Oxymorons and Anti-oxymorons Why “natural anti-aging” can never work
Lithium for Life Extension?
Response to Gretchen Reynolds, Poking Fun at Longevity Science
Open Letter to Google CaLiCo on Priorities in Research
Conference notes: Center for Aging Research, Sherbrooke, QC
Nicotinamide Riboside–Where’s the Beef?
Three Technologies to Watch (1)Thymus regrowth w/ FOXN1; (2) New anti-inflammatory drugs based on ARF6 inhibitors; (3) Telomere length directly affects gene expression
Regeneration in mammals — Ancient capacity is not lost but actively suppressed
What doesn’t kill me makes me stronger
Caloric Restriction, Hormesis and what they teach us about Evolution
Ginseng for Longevity?
Where do we Live? In our quest for a longer life, I often assume “I am my brain”. There are reasons from neuroscience and quantum physics to question this perspective.
What is aging? Most scientists still get it wrong (The body doesn’t just wear out. Death is programmed into our genes.)
Programmed death, H. pylori and the legacy of George Williams (evolution and gut bacteria)
MYC: bad and good, but more bad than good
Do we really need epidemiology to tell us to get off our duffs? (Common sense experience about exercise and sedentary time)
Anti-Aging Pills in the News (Novartis and Elysium Health)
Ideology is Holding Back Aging Research
“What Looks like Cooperation is Really Selfishness” (Critique of the Selfish Gene)
Kill Senescent Cells Before They Kill You
Tomorrow’s Anti-Aging Therapies, Available Today (Bioviva)
Fertility is Kaput, but Life Goes On (Post-Reproductive Life Span)
Telomerase Does Not Cause Cancer
New Study Correlates Telomere Length with Human Mortality
Caution follows last year’s excitement about GDF11
Review of The Vital Question by Nick Lane, Part 1, Part 2, Part 3
Preserving Insulin Sensitivity–the Anti-Diabetes Diet
Is there an aging clock in the hypothalamus? (Orexin, Neuropeptide Y)
Toward a Pill to Enable Regeneration
Correlation and causation; Nuts and Chocolate
Longo on how you can eat while fasting; Barzilai’s campaign to have aging recognized as a disease
Funding Policies Distort Science
Aging in Microbes
(despite theory that forbids it, there is aging in protozoans and even bacteria)
Update and disclaimer — the Longo Fasting-mimicking Diet, including Recipes
Parkinson’s Disease — Can anything be done?
Overstated claims and oversimple theories, including the
“Simple genetic switch” in C elegans, Autophagy, Glycine & mitochondria,
GDF11 and TGF-β)
Orcas and Elephants–Aging and the Taboo Subject of Population Regulation
Review of Carl Safina’s book, Beyond Words.
Report from Rejuvenation Biotech 2015
(Thymus regeneration, Bruce Ames & Rhonda Patrick, plasma transfusion update
Wuyi Kong and NPRCPs)
HGH and IGF–Promise and Danger
Untested Treatments for Longevity, and How to Test Them
(Redundancy and synergy in combining anti-aging treatments)
Promise of Novel Alzheimer’s Treatments
Growth and Aging; Myostatin and Health
Can botanicals replace metformin? Jiaogulan, Berberine and Gymnema
From Roscoff, with Rotifers – What I learned at the Monod Conference on comparative biology of aging
Does donating blood extend your life expectancy?
Anti-Aging Medicine: Two Paths Diverge – Can aging be reversed with biochemical signals?
We Know Nothing about Longevity Drug Interactions – a proposal for efficiently finding the best dynergies among many potential treatments
Global Consequences of Increased Human Longevity – Life extensionists have an vital interest and responsibility to preserve the planet.
Is Aging Controlled from the Brain? NPY and ALK5
‘One of the most important aging discoveries ever’ “Senolytics” are agents that kill cells that have become senescent (and toxic).
When your doctor suggests statins (Part 1: Mechanism of Action)
Cholesterol and inflammation; Statins and alternatives (Part II)
Politics drives a promising nutraceutical underground Anatabine
Retrotransposons: The Lamarckian Link A mechanism by which the body re-engineers its own genome.
Aging is a Military Coup Systems that evolved to defend the body against invaders turn self-destructive and destroy the body late in life.
Epigenetics of Aging and Prospects for Rejuvenation
“No Animal Dies of Old Age in the Wild” The declining force of natural selection is the foundation of all evolutionary theories of aging. But it doesn’t decline enough to explain anything.
Cell Phones can Cause Cancer – It’s worthwhile to take precautions with microwaves.
A germ theroy of aging? A new paper proposes that plaques in Alzheimer’s Disease come from inflammatory response to brain infections.
Lamarck Update – Evolutionary scientists have assumed for a century that traits acquired in a lifetime can’t be passed to offspring. Now it’s clear they were wrong. How wrong?
Rapamycin Redux – Rapamycin is the most effective life extension drug yet tested in rodents. Is it safe for humans?
CRISPR update – We’re making progress gaining control over gene expression faster than we are learning what to do with our new power.
Video: “Natural Anti-aging” is an oxymoron
Social Correlates of Longevity 1: Social status and depression, activism vs powerlessness
Social Correlates of Longevity 2: Family
Arthritis: Its importance, its ubiquity, and suggested treatment approaches
Nutritional Geometry 1: Most of us eat too much protein
Nutritional Geometry 2: Carb Restriction
Nutritional Geometry 3: Ketosis— benefits & risks of oil-rich diets
Post-Reproductive Life Span in C. elegans—How did worms evolve a life span that continues long beyond the end of their fertility?
Putting the “system” back in Systems Biology (Report from Cold Spring Harbor Asia Conference, October, 2016)
In an age of epigenetics, does antagonistic pleiotropy still make sense?
Traditional Chinese Medicines for Longevity
Do we have to worry about telomeres being “too long”?
Yamanaka Factors (which turn normal cells into stem cells) used to rejuvenate mice
Epigenetics and the Direction of Anti-Aging Science
First fruits of blood plasma research VCAM-1 identified as a blood factor that we have too much of as we age
Glycine and mitochondria The simplest amino acid, taken in large enough quantities, encourages new mitochondrial growth
Fasting-mimicking diet: can you make it a habit?
NFkB beyond Inflammation Many supplements and drugs inhibit NFkB, with multiple benefits
New database of lifespan trials Some surprises include creatine, N-Acetyl cysteine, ginkgo, BHT, and a Chinese herb no one has heard of.
Senolytics against aging: snapshot of a fast-moving field The latest and greatest senolytic agent promises to kill more senescent cells while leaving other cells unharmed.
Is fasting senolytic? One of the many benefits of intermittent fasting may be in killing off a tiny number of senescent cells that are poising us from the inside.
Prolonging life with fecal transplants opening a new area of research: life span of fish is extended just by changing their gut microbiome
The only experimental subject who matters using self-experimentation to create a personalized program
Aging gets personal my mother’s stroke; notes from Geneva symposium; blood plasma transfusions; ideas from Andy Mendelssohn
Preventing Dementia physical exercise; individualized programs
Mitochondria in Aging: I Mechanisms
Mitochondria in Aging: II Remedies
Building the Case that Aging is Controlled from the Brain
New Evidence that Long Telomeres cause Cancer, and Why I Think It’s Wrong
Follow-up on Telomeres: Genetic Studies vs Straight Epidemiology
Is Cancer a Mitochondrial Disease Warburg has a new lease on life
Air Pollution and Life Expectancy
Digging Deeper in Response to Reader Comments
- Aspirin, ibuprofen, neproxen
- Does too much exercise cause areterial calcification?
- Cancer as Atavism
- News from the World of telomerase activation
- Inheriting Telomere Length
- Low Dose Naltrexone
- Extraordinary story of radiation hormesis
- High-profile, misleading “proof” that aging is inevitable
- Disappointing results from Alkahest trials
- NewYorker article on exercise in a pill
- Splicing factors rescue senescent cells
A Dead Theory Still Walks many biologists continue to relate their findings to the Antagonistic Pleiotropy theory, though it has been falsified many times over.
Apologia pro Scientia Sua (an original poem)
The Varieties of Aging in Nature Life spans and also shapes of aging curves vary tremendously. Nature can do what she pleases.
The Other Half of Science Science has become synonymous with “reductionism”, and unexpected findings are being suppressed because they cannot be explained in those terms.