Senolytics against Aging: Snapshot of a Fast-Moving Field

Aging at the cellular level is called “cell senescence”, and it contributes profoundly to whole-body aging.  The most promising near-term prospects for a leap in human life expectancy come from drugs that eliminate senescent cells.  Programs in universities and pharmaceutical labs around the world are racing to develop “senolytic” drugs, defined as agents that can … Read more

New Database of Lifespan Trials

Human Ageing Genomic Resources announced last week their on-line database of animal studies that evaluated drugs and supplements for extended lifespan.  HAGR is a project of the University of Liverpool, spearheaded by João Pedro de Magalhaes, who has been an activist-scientist in aging research since his days as a grad student at Harvard. The database … Read more

NF-kB Beyond Inflammation

At different times, I have written about 8 different anti-inflammatory supplements, including aspirin, ibuprofen, omega 3 oils, curcumin, berberine, resveratrol, ashwaghanda, and boswellia, in addition to eating foods such as ginger, rosemary, tea and several mushroom species with anti-inflammatory effects.  There is good evidence for benefits from each of these individually, but I have no … Read more