Month: March 2021

The paradox: In animal models there is a consistent relationship between eating less and living longer. But studies in humans find that people who are a little overweight live longest. Last week, I introduced this paradox and offered evidence, both that lab animals live longer when they are underfed, and that humans live longer when … Read more

Caloric restriction is the gold standard life extension strategy, validated over thousands of experiments in many animal species. How can we reconcile this with consistent findings that people who are slightly overweight live longer than normal or underweight folks? The one fact that everyone in the field of aging agrees on is that animals fed … Read more