Why not Spermidine?

Spermidine is found naturally in many foods. Blood levels decline with age. Supplementation extends lifespan and healthspan in various species, and lowers mortality in human trials. I have been unable to find toxicity data or any downside to spermidine supplementation, except that the effective dosage may be impractical. “Consistently across species, extra supply of spermidine … Read more

I think I know why methylation clocks are failing

Methylation clocks promise to revolutionize testing of anti-aging interventions in humans, by measuring their effectiveness in a few months instead of having to wait years to see if they affect mortality statistics. But there are signs that the clocks we have can be deceptive. I think this is because the clocks capture aspects of aging … Read more

Michael Levin on Aging and Regeneration

The Levin laboratory has found the developmental blueprint that tells the embryo how it must grow. The language of morphology is not genetic or epigenetic, not biochemical at all, but bioelectric. If, as I and others have speculated, aging is an extension of development into a program of self-destruction, then maybe aging follows a bioelectric … Read more

Dr Mercola Doesn’t Like Seed Oils

I’ve learned a great deal from Dr Mercola over the years. His orientation toward natural approaches to long-term health, using diet and lifestyle in preference to pharmaceuticals, aligns with my own. I agree with most of what he has to say. So, when he launched a campaign vilifying seed oils in the diet, I stood … Read more

News from Harold Katcher’s Lab

The big news: (1) the active ingredient in E5 is exosomes. (2) Young exosomes retain their ability to rejuvenate across mammalian species lines. Work that remains: (1) calibrate a new generation of methylation clocks. (2) Combine removal of old exosomes with addition of young exosomes. Optimize dosage and timing of treatments. What is in E5, … Read more

Exosomes and their Potential for Rejuvenation

Extracellular Vesicles (EVs) have only been studied in the 21st century. Think of them as natural lipid nanoparticles, or endogenous viruses. They transmit information around the body and they’re small enough to be exhaled and carried in the air to communicate with other individuals and even other species. EVs are encapsulated in fats that facilitate entry … Read more

Cellular Rejuvenation Without Yamanaka

The Yamanaka factors (four proteins, abbreviated OSKM) are a treatment that can completely reset any ordinary, functional cell into a pluripotent stem cell, able to regenerate tissues of any type. In the process, the cell loses epigenetic markers of age and reverts to an embryonic state. But differentiated cells are differentiated so they can be … Read more

Eat worms

Aspirin is an old staple for life extension. Lately it has received bad press. For those who wish to replace aspirin, there are two actions that must be considered: anti-inflammatory and blood thinning. There are many good anti-inflammatories, all of which act through similar pathways, so that in the end we don’t know have optimal … Read more